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All Eyes on Alli vs. Obesity Match-Up – Over-the-Counter Weight Loss Drug That Packs a Punch

November 14th, 2022

The launch of Alli (Orlistat) – the first FDA-approved over-the-counter anti-obesity drug – is exciting news for millions of obese and seriously overweight Americans. Alli, which is expected to hit drugstore shelves this summer, is comprised of a reduced-strength formula of the popular weight-loss drug Xenical (orlistat) and is the only weight-loss drug endorsed by the U.S. Food and Drug Administration and made available without a prescription.

Pharmaceutical giant and Alli manufacturer GlaxoSmithKline maintains the product rights to Alli through mutual agreement with Roche, the manufacturer of prescription-only Xenical. Xenical has a steady safety record and has proven to be moderately effective in helping obese individuals lose weight. Studies indicate that when patients take prescription Xenical in combination with a weight-loss program, patients lost an average of 12.4 pounds of weight less in six months — about double the amount lost by patients taking a placebo weight loss drug. Some studies have suggested that Alli, at half the dosage (and approximately one-third the price of prescription Xenical,) is almost as effective.

How it Works

Alli is made of the same chemical structure as Xenical. The drug obstructs dietary fat from being absorbed by the body after food consumption. The undigested fat is then removed from the body as bowel waste. As such, the drug it leads to a reduction in the absorption of fat by as much as 30%.
Alli will be available in 60 milligram capsules, to be taken three times a day with meals that contain fat. Officials at GlaxoSmithKline said that the drug works by “blocking about 25 percent of the fat in food a person eats. Because of the way it works, Alli must be used in conjunction with a reduced-calorie, low-fat diet containing about 15 grams of fat per meal.” GlaxoSmithKline also reported that the drug helps people lose 50 percent more weight than dieting alone. Alli will cost consumers $12 to $25 a week.
“This is the only FDA-approved, over-the-counter weight-loss drug product,” Dr. Charles J. Ganley, the FDA’s director of the Division of Over-The-Counter Drug Products, said during a teleconference. “There are some products, primarily dietary supplements, that make weight-loss claims and those are not FDA-approved, although they are permitted to make these claims.”

Alli vs. The U.S. Obesity Epidemic

The FDA’s approval of the first over-the-counter drug for weight loss comes as the United States and other Western nations are struggling with an unprecedented obesity epidemic. According to the U.S. National Center for Health Statistics, 30 percent of American adults 20 years of age and older — more than 60 million people — are obese. An Additional 36 percent of Americans are considered overweight.

But is Alli the magic diet pill that dieters have been asking for? Maybe not, according to some researchers. Dr. Raj Padwal, an assistant professor of general internal medicine at the University of Alberta, is unsure of about the efficacy of the drug. “People may only lose 1 to 2 kilograms (2.2 to 4.4 pounds) on this half-strength dose [of Xenical]. Whether that is worthwhile is questionable,” said Padwal. “The occasional patient may benefit, but many patients may not. For those patients who need extra incentive to adhere to a low-fat diet, the drug may help.”

Alli is likely to cause very limited direct harm, but may also cause limited good, according to Dr. David L. Katz, an associate professor of public health and director of the Prevention Research Center at the Yale University School of Medicine. “[Alli] is a relatively ineffective weight-loss aid,” he said. “If availability of the drug distracts people from the tried-and-true approach to weight control – eating well and being active – then the FDA decision could prove more harmful than helpful, in spite of good intentions.”

Side Effects

According to research and trials, Alli has very few negative side effects. However, users be warned: eating a meal with too much fat while taking the drug can result in bowel changes such as loose stools, according to the FDA. Side effects typically occur in the first weeks of treatment and can be managed by following the recommended diet of about 15 grams of fat per meal, GlaxoSmithKline said. It is also recommended that users take a multivitamin once a day at bedtime because the drug can interfere with the absorption of some vitamins.
Other side effects may include:

o Oily skin spotting

o Gas with discharge

o Fecal urgency

o Fatty or oily stools

o Frequent bowel movements

Before Taking Alli

Prior consultation with a doctor is recommended before taking Alli. Be sure to:

o Tell your doctor or pharmacist if you are allergic to orlistat or any other drugs.

o Tell your doctor or pharmacist what prescription and nonprescription drugs you are taking, especially anticoagulants (”blood thinners”) such as warfarin (Coumadin); medications for diabetes, such as glipizide (Glucotrol), glyburide (DiaBeta, Dynase, Micronase), metformin (Glucophage), and insulin; other medications for weight loss; pravastatin (Pravachol); vitamins such as beta-carotene and vitamins A, E, and K; and herbal products. If you are taking cyclosporine (Neoral, Sandimmune), take it 2 hours before or 2 hours after orlistat.

o Tell your doctor if you have or have ever had anorexia nervosa or bulimia, gallstones, thyroid disease, diabetes, kidney problems, or if you consistently have problems absorbing food (malabsorption syndrome).

o Tell your doctor if you are pregnant, plan to become pregnant, or are bre

Some Natural Diet Products and Supplements

October 14th, 2022

There is a huge market for diet products today. This $23-billion industry is on the verge of producing even more. The release of medications like Xenical, Alli, and other weight loss drugs have helped raise the profile of the industry. The good news is that these developments have raised awareness about obesity and the many health concerns connected with this condition.

That’s where natural weight loss supplements come in. Not everyone will be able to buy Xenical for their obesity. In fact, certain chemicals may conflict with other physical conditions or other medications. When you take medicines, you need to be very careful with choosing diet products which don’t conflict with your body’s processes. Because of this, people have begun to look at what nature has to offer to help them lose the extra weight. Such products are taken from naturally occurring substances in the body or in herbs and other plants.

Hoodia is an example of an herb that has been touted to help in the battle against obesity. People who buy Hoodia can rely on a long history. African bushmen have been consuming the plant for decades, and it was only in the sixties that scientists began to study natural weight loss supplements and diet products based on the hoodia gordonii plant. They’ve even isolated the active ingredient, p57, which works as a diet suppressant. This makes you lose the desire to eat for a longer period of time than usual. Unfortunately, because of its popularity, numerous products have jumped on the bandwagon, claiming to contain hoodia when in fact only a small portion of the active chemical is in them. The consumer needs to exercise great care in buying this from the market.

Another one of the more popular natural weight loss supplements on the market is L-glutamine. This substance has a lot of health benefits, including quicker wound recovery, immune system boosts, and protection for the liver if you’re undergoing chemotherapy. It occurs naturally in the body, but there are glutamine capsules available on the market. In fact, many fitness and diet products contain this substance. Just like any other medication, taking too much will result in unpleasant side effects, namely an upset stomach. Consumers must also be careful not to think that L-glutamine is a miracle weight loss drug, because it isn’t. However, combined with proper exercise, it may help suppress certain food cravings.

Resveratrol is yet another one of the natural weight loss supplements based on plants. This chemical was isolated as the main ingredient in the French paradox. People in France typically eat a high-fat diet and drink red wine. While an alcohol-and-fat diet is normally a deadly combination, that isn’t the case with the French. It was found that the resveratrol in red wine helped them live longer in spite of this. The chemical works by restricting calories, lowering body fat, and changing patterns of metabolism. This is one of those diet products which don’t only help you lose weight, but also keep you healthy and fit.

Of course, the decision on which kind of supplement to take is up to you. Each person will have his own needs that may be supplied either by chemical or natural weight loss supplements. Howe